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KMID : 0352119930090020140
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Journal of Kyung Hee University
1993 Volume.9 No. 2 p.140 ~ p.145
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Pulse Rate, mean Arterial Blood pressure, and Local Cerebral Blood Flow Variations of Response to High Dose Pentobarbital Sodium in the Rats
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Abstract
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We experimented on 15 male Sprague-Dawley rats weighing between 330 and 450g for the evalution of pulse rats (PR), Mean arterial pressuse (MAP) and Local cerebral blood flow (CBF) in Variations of response to high dose pentobarbital sodium
administered
intraperitoneally.
The amount of high dose pentobarbital sodium was 60 mg/kg. The estimates of PR, MAP and CBF were made at 1 hour, 1 hour 30 minutes, 2 hour, 2 hour 30 minutes and 3 hour.
We divided into two groups, Group A (n=9) and Group B (n=6).
We compared with group A (n=9); one dose of pentobarbital sodium 60 mg/kg was injected intraperitoneally and maintained, and group B (n=6); initially one dose of pentibarbotal sodium 60 mg/kg was injected intraperitoneally & pentobarbital sodium
4
mg/kg
was injected intraperitoneally every 30 minutes for maintenance of Anesthesia. Group A (n=9) showed the constant values of PR and MAP during the experimental study. But, CBF were markedly decreased after 1 hour Anestnesia and Thereafter CBF were
gradually recovering towards normal values with the lapse of time, expecially CBF were more increased after 2 hour**, 2 hour 30 minutes** and 3 hour (p**<0.01) than after 1 hour. Group B (n=6) revealed the constant values of PR and MAP, but,
initially,
CBF were markedly decreased after 1 hour and CBF was slightly increased after 2 hour 30 minutes and 3 hour (p **< 0.05).
We concluded as the follows. High dose pentobarbital sodium 60 mg/kg for the anesthetic effects in the rats were to keep constant values of PR & MAP, but CBF were initially markedly decreased after 1 hour and thereafter slightly increased towards
normal
values.
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KEYWORD
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